Beta-1 adrenergic receptor
Details
- Name
- Beta-1 adrenergic receptor
- Synonyms
-
- ADRB1R
- B1AR
- Beta-1 adrenoceptor
- Beta-1 adrenoreceptor
- Gene Name
- ADRB1
- Organism
- Humans
- Amino acid sequence
-
>lcl|BSEQ0010188|Beta-1 adrenergic receptor MGAGVLVLGASEPGNLSSAAPLPDGAATAARLLVPASPPASLLPPASESPEPLSQQWTAG MGLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVV WGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARGLVC TVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIM AFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPSPSPVPAPAPPPGPPRPAAAAATAP LANGRAGKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRELVPDRLFV FFNWLGYANSAFNPIIYCRSPDFRKAFQRLLCCARRAARRRHATHGDRPRASGCLARPGP PPSPGAASDDDDDDVVGATPPARLLEPWAGCNGGAAADSDSSLDEPCRPGFASESKV
- 数量的残留物
- 477
- 摩尔cular Weight
- 51322.1
- Theoretical pI
- 9.03
- GO Classification
-
Functionsalpha-2A adrenergic receptor binding/beta-adrenergic receptor activity/beta1-adrenergic receptor activity/epinephrine binding/去甲肾上腺素结合/PDZ domain binding/protein heterodimerization activity/Ras guanyl-nucleotide exchange factor activity/receptor signaling protein activityProcessesactivation of adenylate cyclase activity/adenylate cyclase-activating adrenergic receptor signaling pathway/brown fat cell differentiation/cell-cell signaling/diet induced thermogenesis/fear response/heat generation/intracellular signal transduction/negative regulation of multicellular organism growth/positive regulation of cAMP biosynthetic process/positive regulation of cAMP-mediated signaling/positive regulation of GTPase activity/positive regulation of heart rate by epinephrine-norepinephrine/positive regulation of the force of heart contraction by epinephrine-norepinephrine/response to cold/temperature homeostasis/vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressureComponents早期内体/integral component of plasma membrane/plasma membrane
- General Function
- Receptor signaling protein activity
- Specific Function
- Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling.
- Pfam Domain Function
-
- 7tm_1 (PF00001)
- Transmembrane Regions
- 56-84 94-120 133-154 173-196 223-248 320-349 355-377
- Cellular Location
- Cell membrane
- Gene sequence
-
>lcl|BSEQ0010189|Beta-1 adrenergic receptor (ADRB1) ATGGGCGCGGGGGTGCTCGTCCTGGGCGCCTCCGAGCCCGGTAACCTGTCGTCGGCCGCA CCGCTCCCCGACGGCGCGGCCACCGCGGCGCGGCTGCTGGTGCCCGCGTCGCCGCCCGCC TCGTTGCTGCCTCCCGCCAGCGAAAGCCCCGAGCCGCTGTCTCAGCAGTGGACAGCGGGC ATGGGTCTGCTGATGGCGCTCATCGTGCTGCTCATCGTGGCGGGCAATGTGCTGGTGATC GTGGCCATCGCCAAGACGCCGCGGCTGCAGACGCTCACCAACCTCTTCATCATGTCCCTG GCCAGCGCCGACCTGGTCATGGGGCTGCTGGTGGTGCCGTTCGGGGCCACCATCGTGGTG TGGGGCCGCTGGGAGTACGGCTCCTTCTTCTGCGAGCTGTGGACCTCAGTGGACGTGCTG TGCGTGACGGCCAGCATCGAGACCCTGTGTGTCATTGCCCTGGACCGCTACCTCGCCATC ACCTCGCCCTTCCGCTACCAGAGCCTGCTGACGCGCGCGCGGGCGCGGGGCCTCGTGTGC ACCGTGTGGGCCATCTCGGCCCTGGTGTCCTTCCTGCCCATCCTCATGCACTGGTGGCGG GCGGAGAGCGACGAGGCGCGCCGCTGCTACAACGACCCCAAGTGCTGCGACTTCGTCACC AACCGGGCCTACGCCATCGCCTCGTCCGTAGTCTCCTTCTACGTGCCCCTGTGCATCATG GCCTTCGTGTACCTGCGGGTGTTCCGCGAGGCCCAGAAGCAGGTGAAGAAGATCGACAGC TGCGAGCGCCGTTTCCTCGGCGGCCCAGCGCGGCCGCCCTCGCCCTCGCCCTCGCCCGTC CCCGCGCCCGCGCCGCCGCCCGGACCCCCGCGCCCCGCCGCCGCCGCCGCCACCGCCCCG CTGGCCAACGGGCGTGCGGGTAAGCGGCGGCCCTCGCGCCTCGTGGCCCTGCGCGAGCAG AAGGCGCTCAAGACGCTGGGCATCATCATGGGCGTCTTCACGCTCTGCTGGCTGCCCTTC TTCCTGGCCAACGTGGTGAAGGCCTTCCACCGCGAGCTGGTGCCCGACCGCCTCTTCGTC TTCTTCAACTGGCTGGGCTACGCCAACTCGGCCTTCAACCCCATCATCTACTGCCGCAGC CCCGACTTCCGCAAGGCCTTCCAGGGACTGCTCTGCTGCGCGCGCAGGGCTGCCCGCCGG CGCCACGCGACCCACGGAGACCGGCCGCGCGCCTCGGGCTGTCTGGCCCGGCCCGGACCC CCGCCATCGCCCGGGGCCGCCTCGGACGACGACGACGACGATGTCGTCGGGGCCACGCCG CCCGCGCGCCTGCTGGAGCCCTGGGCCGGCTGCAACGGCGGGGCGGCGGCGGACAGCGAC TCGAGCCTGGACGAGCCGTGCCGCCCCGGCTTCGCCTCGGAATCCAAGGTGTAG
- Chromosome Location
- 10
- Locus
- 10q24-q26
- External Identifiers
-
Resource Link UniProtKB ID P08588 UniProtKB Entry Name ADRB1_HUMAN GenBank Protein ID 178200 GenBank Gene ID J03019 GenAtlas ID ADRB1 HGNC ID HGNC:285 - General References
-
- Frielle T, Collins S, Daniel KW, Caron MG, Lefkowitz RJ, Kobilka BK: Cloning of the cDNA for the human beta 1-adrenergic receptor. Proc Natl Acad Sci U S A. 1987 Nov;84(22):7920-4. [Article]
- Moore JD, Mason DA, Green SA, Hsu J, Liggett SB: Racial differences in the frequencies of cardiac beta(1)-adrenergic receptor polymorphisms: analysis of c145A>G and c1165G>C. Hum Mutat. 1999 Sep 19;14(3):271. [Article]
- Deloukas P, Earthrowl ME, Grafham DV, Rubenfield M, French L, Steward CA, Sims SK, Jones MC, Searle S, Scott C, Howe K, Hunt SE, Andrews TD, Gilbert JG, Swarbreck D, Ashurst JL, Taylor A, Battles J, Bird CP, Ainscough R, Almeida JP, Ashwell RI, Ambrose KD, Babbage AK, Bagguley CL, Bailey J, Banerjee R, Bates K, Beasley H, Bray-Allen S, Brown AJ, Brown JY, Burford DC, Burrill W, Burton J, Cahill P, Camire D, Carter NP, Chapman JC, Clark SY, Clarke G, Clee CM, Clegg S, Corby N, Coulson A, Dhami P, Dutta I, Dunn M, Faulkner L, Frankish A, Frankland JA, Garner P, Garnett J, Gribble S, Griffiths C, Grocock R, Gustafson E, Hammond S, Harley JL, Hart E, Heath PD, Ho TP, Hopkins B, Horne J, Howden PJ, Huckle E, Hynds C, Johnson C, Johnson D, Kana A, Kay M, Kimberley AM, Kershaw JK, Kokkinaki M, Laird GK, Lawlor S, Lee HM, Leongamornlert DA, Laird G, Lloyd C, Lloyd DM, Loveland J, Lovell J, McLaren S, McLay KE, McMurray A, Mashreghi-Mohammadi M, Matthews L, Milne S, Nickerson T, Nguyen M, Overton-Larty E, Palmer SA, Pearce AV, Peck AI, Pelan S, Phillimore B, Porter K, Rice CM, Rogosin A, Ross MT, Sarafidou T, Sehra HK, Shownkeen R, Skuce CD, Smith M, Standring L, Sycamore N, Tester J, Thorpe A, Torcasso W, Tracey A, Tromans A, Tsolas J, Wall M, Walsh J, Wang H, Weinstock K, West AP, Willey DL, Whitehead SL, Wilming L, Wray PW, Young L, Chen Y, Lovering RC, Moschonas NK, Siebert R, Fechtel K, Bentley D, Durbin R, Hubbard T, Doucette-Stamm L, Beck S, Smith DR, Rogers J: The DNA sequence and comparative analysis of human chromosome 10. Nature. 2004 May 27;429(6990):375-81. [Article]
- Pak Y, Pham N, Rotin D: Direct binding of the beta1 adrenergic receptor to the cyclic AMP-dependent guanine nucleotide exchange factor CNrasGEF leads to Ras activation. Mol Cell Biol. 2002 Nov;22(22):7942-52. [Article]
- He J, Bellini M, Xu J, Castleberry AM, Hall RA: Interaction with cystic fibrosis transmembrane conductance regulator-associated ligand (CAL) inhibits beta1-adrenergic receptor surface expression. J Biol Chem. 2004 Nov 26;279(48):50190-6. Epub 2004 Sep 9. [Article]
- Cheng SB, Quinn JA, Graeber CT, Filardo EJ: Down-modulation of the G-protein-coupled estrogen receptor, GPER, from the cell surface occurs via a trans-Golgi-proteasome pathway. J Biol Chem. 2011 Jun 24;286(25):22441-55. doi: 10.1074/jbc.M111.224071. Epub 2011 May 2. [Article]
- Mason DA, Moore JD, Green SA, Liggett SB: A gain-of-function polymorphism in a G-protein coupling domain of the human beta1-adrenergic receptor. J Biol Chem. 1999 Apr 30;274(18):12670-4. [Article]
- Borjesson M, Magnusson Y, Hjalmarson A, Andersson B: A novel polymorphism in the gene coding for the beta(1)-adrenergic receptor associated with survival in patients with heart failure. Eur Heart J. 2000 Nov;21(22):1853-8. [Article]
- Ranade K, Jorgenson E, Sheu WH, Pei D, Hsiung CA, Chiang FT, Chen YD, Pratt R, Olshen RA, Curb D, Cox DR, Botstein D, Risch N: A polymorphism in the beta1 adrenergic receptor is associated with resting heart rate. Am J Hum Genet. 2002 Apr;70(4):935-42. Epub 2002 Feb 18. [Article]
Drug Relations
- Drug Relations
-
DrugBank ID Name Drug group Pharmacological action? Actions Details DB00187 Esmolol approved, withdrawn yes antagonist Details DB00195 Betaxolol approved, investigational yes antagonist Details DB00221 Isoetharine approved yes agonist Details DB00264 Metoprolol approved, investigational yes antagonist Details DB00335 Atenolol approved yes antagonist Details DB00373 Timolol approved yes antagonist Details DB00571 Propranolol approved, investigational yes antagonist Details DB00612 Bisoprolol approved yes antagonist Details DB00841 Dobutamine approved yes agonist Details DB00866 Alprenolol experimental, withdrawn yes antagonist Details DB00960 心得乐 approved, investigational yes partial agonist Details DB01064 Isoprenaline approved, investigational yes agonist Details DB01102 Arbutamine approved yes agonist Details DB01193 Acebutolol approved, investigational yes partial agonist Details DB01203 Nadolol approved yes antagonist Details DB01210 Levobunolol approved yes antagonist Details DB01214 Metipranolol approved yes antagonist Details DB00521 Carteolol approved yes partial agonist Details DB00598 Labetalol approved yes antagonist Details DB00668 Epinephrine approved, vet_approved yes agonist Details DB01136 Carvedilol approved, investigational yes antagonist Details DB01151 Desipramine approved, investigational unknown other Details DB01295 Bevantolol experimental yes antagonist Details DB01297 Practolol approved yes antagonist Details DB01580 Oxprenolol approved yes antagonist Details DB01359 Penbutolol approved, investigational yes antagonistpartial agonist Details DB00368 Norepinephrine approved yes agonist Details DB04855 Dronedarone approved unknown antagonist Details DB04861 Nebivolol approved, investigational yes antagonist Details DB06262 Droxidopa approved, investigational yes agonist Details 18beplay下载 Salbutamol approved, vet_approved unknown agonist 18beplay下载 DB00489 Sotalol approved yes antagonist Details DB01291 Pirbuterol approved unknown agonist Details DB01288 Fenoterol approved, investigational unknown agonist Details DB00397 Phenylpropanolamine 批准、vet_approved撤回 unknown agonist Details DB01407 Clenbuterol approved, investigational, vet_approved unknown agonist Details DB08347 4-{[(2S)-3-(tert-butylamino)-2-hydroxypropyl]oxy}-3H-indole-2-carbonitrile experimental unknown Details DB08558 2-HYDROXYMETHYL-6-OCTYLSULFANYL-TETRAHYDRO-PYRAN-3,4,5-TRIOL experimental unknown Details DB08807 Bopindolol experimental yes partial agonist Details DB08808 Bupranolol experimental yes antagonist Details DB00852 Pseudoephedrine approved unknown agonistpartial agonist Details DB04846 Celiprolol approved, investigational yes antagonist Details DB01363 Ephedra sinica root nutraceutical yes agonist Details DB06216 Asenapine approved unknown antagonist Details DB00408 Loxapine approved unknown binder Details DB00248 Cabergoline approved unknown binder Details DB09068 Vortioxetine approved, investigational unknown ligand Details DB09013 Befunolol experimental unknown Details DB00983 Formoterol approved, investigational unknown agonist Details DB00938 Salmeterol approved unknown inverse agonist Details DB00871 Terbutaline approved unknown antagonist Details DB01917 Putrescine experimental unknown Details DB03566 Spermidine experimental unknown Details DB00127 Spermine experimental, nutraceutical unknown Details DB01182 Propafenone approved unknown antagonist Details DB09351 Levobetaxolol approved, investigational yes antagonist Details DB13781 Xamoterol approved yes partial agonist Details DB09204 Arotinolol investigational yes antagonist Details DB00555 Lamotrigine approved, investigational unknown 抑制剂 Details DB11124 Racepinephrine approved yes agonist Details DB11278 DL-Methylephedrine approved yes agonist Details DB00243 Ranolazine approved, investigational no antagonist Details DB01238 Aripiprazole approved, investigational unknown ligand Details DB01364 Ephedrine approved yes agonist Details DB08893 Mirabegron approved unknown agonist Details DB01118 Amiodarone approved, investigational yes 抑制剂downregulator Details DB00182 Amphetamine approved, illicit, investigational unknown agonist Details DB00540 Nortriptyline approved unknown antagonist Details DB00726 Trimipramine approved unknown binder Details DB00334 Olanzapine approved, investigational no 抑制剂 Details DB00217 Bethanidine approved unknown antagonist Details DB01365 Mephentermine approved unknown agonist Details DB06726 Bufuralol experimental unknown antagonist Details DB13345 Dihydroergocristine approved, experimental yes antagonistagonist Details DB01049 Ergoloid mesylate approved yes antagonistagonist Details DB11273 Dihydroergocornine approved yes antagonistagonist Details DB11278 DL-Methylephedrine approved yes agonist Details DB00715 Paroxetine approved, investigational unknown 抑制剂 Details DB00785 Cryptenamine approved unknown 抑制剂potentiator Details DB00867 Ritodrine approved, investigational yes agonistdownregulator Details DB00264 Metoprolol approved, investigational unknown 抑制剂 Details