Antihypertensive Agents
- Name
- Antihypertensive Agents
- Accession Number
- DBCAT000410
- Description
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Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS.
- ATC Classification
- Drugs
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Drug Drug Description Reserpine 为treatment of hypertension Bethanidine 为treatment of hypertension. Nitroprusside A direct acting vasodilator used to treat hypertension, to induce controlled hypotension to reduce postoperative bleeding, and to manage acute heart failure. Minoxidil An antihypertensive vasodilating agent used for resistant hypertension that is symptomatic or has caused end organ damage. Prazosin An alpha-blocker that causes a decrease in total peripheral resistance and is used to treat hypertension. Bosentan A dual endothelin receptor antagonist used to treat pulmonary arterial hypertension. Clonidine An alpha-2 adrenergic agonist used to treat hypertension and severe cancer pain, among other conditions, and to treat withdrawal symptoms from various substances. It is also used to aid in the diagnosis of pheochromocytoma and to prevent migraines. Doxazosin An alpha-1 adrenergic receptor used to treat mild to moderate hypertension and urinary obstruction due to benign prostatic hyperplasia. Mecamylamine A nicotine antagonist used to treat moderate to severe essential hypertension and uncomplicated malignant hypertension. Guanfacine An alpha-2A adrenergic receptor agonist used to treat ADHD. Trimethaphan For the controlled reduction of blood pressure during surgery and in the treatment of hypertensive emergencies. Hydralazine An antihypertensive agent used for the management of essential hypertension or severe hypertension associated with conditions requiring immediate action, heart failure, and pre-eclampsia or eclampsia . Pargyline 为treatment of moderate to severe hypertension. Debrisoquine 为treatment of moderate and severe hypertension, either alone or as an adjunct, and for the treatment of renal hypertension. Pinacidil Pinacidil is a cyanoguanidine drug that acts by opening ATP-sensitive potassium channels, leading to peripheral vasodilatation of arterioles and decreasing peripheral vascular resistance. The above processes result in reduced blood... Indoramin Indoramin is a discontinued piperidine antiadrenergic drug with the trade names Baratol and Doralese. It is a selective alpha-1 adrenergic antagonist with no reflex tachycardia and direct myocardial depression action. Trimazosin Trimazosin is a sympatholytic alpha blocker. Moxonidine An imidazoline/α-2 receptor agonist used to treat hypertension, especially in cases where ACE inhibitors, β-blockers, calcium channel blockers, and thiazides are not appropriate or provide inadequate blood pressure control. Rilmenidine An I1-imidazoline receptor agonist used to treat hypertension. Ketanserin Ketanserin has been investigated for the treatment of Septic Shock, Severe Sepsis, and Diabetic Foot Ulcer. Dihydralazine 在临床t Dihydralazine正在调查中rial NCT00311974 (The Effect of Dihydralazine on Kidney Function and Hormones in Healthy Individuals). Urapidil A combination adrenergic antagonist and serotonin agonist given orally for the treatment of essential hypertension and intravenously in hypertensive emergencies. Endralazine Not Annotated Cadralazine Not Annotated Bietaserpine Not Annotated Valsartan An angiotensin-receptor blocker used to manage hypertension alone or in combination with other antihypertensive agents and to manage heart failure in patients who are intolerant to ACE inhibitors. Ramipril An ACE inhibitor used for the management of hypertension and the reduction of cardiovascular mortality following myocardial infarction in hemodynamically stable patients with clinical signs of congestive heart failure. Betaxolol A cardioselective beta blocking agent commonly used to treat hypertension and elevated intraocular pressure (when administered ophthalmically). Remikiren 为treatment of hypertension and heart failure Torasemide A diuretic used to treat hypertension and edema associated with heart failure, renal failure, or liver disease. Guanadrel Used to treat and control hypertension. Metoprolol A beta-blocker used in the treatment of hypertension and angina, and used to reduce mortality due to myocardial infarction. Isradipine A dihydropyridine calcium channel blocker used for the treatment of hypertension. Olmesartan An angiotensin receptor blocker (ARB) used in the treatment of hypertension. Travoprost A prostaglandin analog used in the treatment of elevated intraocular pressure due to open angle glaucoma or ocular hypertension. Chlorthalidone A diuretic used to treat hypertension or edema caused by heart failure, renal failure, hepatic cirrhosis, estrogen therapy, and other conditions. Atenolol A synthetic beta-1 selective blocker used in the management of hypertension and chronic angina, and to reduce mortality in known or suspected myocardial infarction in hemodynamically stable patients. Diltiazem A calcium channel blocker used to treat hypertension and to manage chronic stable angina. Treprostinil A prostacyclin vasodilator for the treatment of pulmonary arterial hypertension to relieve exercise associated symptoms and to prevent clinical deterioration after stopping epoprostenol. Amlodipine A calcium channel blocker used to treat hypertension and angina. Nimodipine A calcium channel blocker used to improve neurological outcomes in patients with subarachnoid hemorrhage due to a ruptured intracranial aneurysm. Nisoldipine A calcium channel blocker used as monotherapy or combined with other drugs for the treatment of hypertension. Bendroflumethiazide A diuretic used to suppress lactation and to treat hypertension and edema. Fosinopril An ACE inhibitor used to treat mild to moderate hypertension, congestive heart failure, and to slow the progression of renal disease in hypertensive diabetics. Trandolapril A prodrug of an ACE inhibitor used to treat hypertension, congestive heart failure, and to improve survival following a myocardial infarction. Metolazone A thiazide-like diuretic used to treat hypertension. Lercanidipine A calcium channel blocker for the management of hypertension. Benazepril An ACE inhibitor prodrug used to treat hypertension. Enalapril A prodrug of an ACE inhibitor used to treat hypertension and congestive heart failure. Labetalol An alpha and beta adrenergic antagonist used to treat hypertension, angina, and sympathetic overactivity syndrome. Cyclothiazide Cyclothiazide is indicated as adjunctive therapy in edema associated with congestive heart failure, hepatic cirrhosis, and corticosteroid and estrogen therapy. It is also indicated in the management of hypertension either... Bisoprolol A beta-1 adrenergic blocking agent used to prevent myocardial infarction and heart failure and to treat mild to moderate hypertension. Candoxatril Candoxatril is the orally-active prodrug of candoxatrilat (UK-73967), a potent neutral endopeptidase (NEP) inhibitor. Nicardipine 钙通道阻滞剂用于商店rt-term treatment of hypertension and chronic stable angina. Guanabenz An alpha-2 adrenergic agonist used to treat hypertension. Latanoprost An isopropyl ester prodrug used to treat increased intraocular pressure. Losartan An angiotensin receptor blocker used to treat hypertension and diabetic nephropathy, and is used to reduce the risk of stroke. Moexipril An angiotensin converting enzyme inhibitor prodrug used to treat hypertension. 酚妥拉明 An alpha adrenergic antagonist used to reverse soft tissue anesthesia. Lisinopril An ACE inhibitor used to treat hypertension, heart failure, and acute myocardial infarction. Hydroflumethiazide A thiazide diuretic used to treat hypertension as well as edema due to congestive heart failure and liver cirrhosis. Cryptenamine 为treatment of hypertension. Perindopril An ACE inhibitor prodrug used to treat hypertension, mild to moderate congestive heart failure, and to reduce cardiovascular risk in patients with hypertension or post-myocardial infarction. Candesartan cilexetil An angiotensin receptor blocker used to treat hypertension, systolic hypertension, left ventricular hypertrophy, and delay progression of diabetic nephropathy. Tolazoline A vasodilator used to treat pulmonary artery anomalies. Fenoldopam A dopamine D1 receptor agonist used for the short term management of hypertension. Indapamide A thiazide diuretic used to treat hypertension as well as edema due to congestive heart failure. Dorzolamide A carbonic anhydrase inhibitor used to treat high intraocular pressure in ocular hypertension and open angle glaucoma. Eprosartan An ARB used to treat hypertension, diabetic nephropathy, and congestive heart failure. Chlorothiazide A thiazide diuretic used to treat hypertension and edema in congestive heart failure, hepatic cirrhosis, and corticosteroid and estrogen therapy. Quinapril An ACE inhibitor prodrug used to treat hypertension, congestive heart failure, and slow rate of progression of renal disease. Omapatrilat 为treatment of hypertension. Bimatoprost A prostaglandin analog used to treat hypotrichosis of the eyelashes and intraocular pressure in open angle glaucoma or ocular hypertension. Phenoxybenzamine An alpha adrenergic antagonist used to treat pheochromocytoma and episodes of hypertension and sweating. Telmisartan An ARB used to treat hypertension, diabetic nephropathy, and congestive heart failure. 甲基多巴 A centrally-acting alpha-2 adrenergic agonist used to manage hypertension alone or in combination with hydrochlorothiazide, and to treat hypertensive crises. Hydrochlorothiazide A thiazide diuretic used to treat edema associated with a number of conditions, and hypertension. Trichlormethiazide Used in the treatment of oedema (including that associated with heart failure) and hypertension. Felodipine A calcium channel blocker used to treat hypertension. Irbesartan An angiotensin receptor blocker used to treat hypertension, delay progression of diabetic nephropathy, and treat congestive heart failure. Nitrendipine A dihydropyridine calcium channel blocker indicated in the treatment of arterial hypertension. Pentolinium Used to produce controlled hypotension during surgical procedures and in hypertensive crises. Diazoxide A non diuretic benzothiadiazine indicated for the management of hypoglycemia in patients who produce an excess of insulin caused by a variety of conditions. Carvedilol A non selective beta-adrenergic antagonist used to treat mild to severe chronic heart failure, hypertension, and left ventricular dysfunction following myocardial infarction in clinically stable patients. Bretylium A norepinephrine release inhibitor used for the prophylaxis and therapy of ventricular fibrillation, as well as the treatment of life-threatening ventricular arrhythmias. Guanethidine An antihypertensive agent used in the management of moderate and severe hypertension, either alone or as an adjunct, and for the management of renal hypertension. Acebutolol A selective β1-receptor antagonist used for the management of hypertension and ventricular premature beats in adults. Captopril An ACE inhibitor used for the management of essential or renovascular hypertension, congestive heart failure, left ventricular dysfunction following myocardial infarction, and nephropathy. Metipranolol A beta-adrenergic antagonist used for the reduction of elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma. Epoprostenol A vasodilator and platelet aggregation inhibitor used for the management of primary pulmonary hypertension and pulmonary hypertension in patients with heart failure. Bepridil 为treatment of hypertension, and chronic stable angina (classic effort-associated angina). Polythiazide A thiazide diuretic used in the management of hypertension and treatment of edema. Cilazapril An ACE inhibitor used for the management of hypertension and heart failure. Saprisartan Saprisartan is used in the treatment of hypertension and heart failure. Spirapril Spirapril is an ACE inhibitor class drug used to treat hypertension. Mibefradil 为treatment of angina and high blood pressure. Tienilic acid 为treatment of hypertension. Celiprolol A beta-blocker for the management of hypertension and angina pectoris. Nebivolol A beta blocking agent used to treat hypertension and aid in the management of heart failure. Lofexidine A centrally acting alpha2-adrenergic agonist used for the symptomatic treatment of acute opioid withdrawal syndrome to facilitate abrupt opioid discontinuation in adults. N1,N11-Diethylnorspermine Investigated for use/treatment in renal cell carcinoma, pancreatic cancer, melanoma, and lung cancer. Nilvadipine A calcium channel blocker used to manage arterial hypertension. Unoprostone A prostaglandin analogue used to lower intraocular pressure in patients with open-angle glaucoma or ocular hypertension who are clinically unresponsive to other ocular antihypertensive agents. Ferulic acid Not Available Temocapril Temocaprilis an ACE inhibitor primarily indicated in the treatment of hypertension and congestive heart failure, diabetic nephropathy, and improvement of prognosis for coronary artery diseases (including acute myocardial infarction). Indenolol Indenolol is a drug of the beta-adrenergic blocker class. Hexamethonium A nicotinic cholinergic antagonist often referred to as the prototypical ganglionic blocker. It is poorly absorbed from the gastrointestinal tract and does not cross the blood-brain barrier. It has been... Aliskiren A direct renin inhibitor used to manage hypertension. Nicorandil A vasodilatory drug that functions through potassium channels and intracellular cGMP concentrations commonly used to treat angina. Efonidipine 为treatment of hypertension. Lacidipine A lipophilic dihydropyridine calcium channel blocker with a slow onset of action used to treat hypertension. Manidipine A dihydropyridine calcium channel blocker used to treat hypertension. Niguldipine Niguldipine is a calcium channel blocker drug (CCB) with a1-adrenergic antagonist properties. Enalaprilat An antihypertensive agent used for the management of hypertension when oral therapy is not practical. Selexipag A non prostanoid IP prostacyclin receptor agonist used to treat pulmonary arterial hypertension. Talinolol Talinolol has been investigated for the basic science of Gastrointestinal Motility Disorder. Imidapril An ACE inhibitor used in the treatment of essential hypertension. BQ-123 BQ-123 has been investigated for the basic science and treatment of Coronary Artery Disease, Aorto-coronary Bypass Grafting, and ST-Elevation Myocardial Infarction. Naftopidil Naftopidil has been investigated for the treatment of Disorder of Urinary Stent. Tetrahydropalmatine Tetrahydropalmatine is under investigation in clinical trial NCT02118610 (Treatment of Schizophrenia With L-tetrahydropalmatine (l-THP): a Novel Dopamine Antagonist With Anti-inflammatory and Antiprotozoal Activity). Zofenopril An ACE inhibitor indicated in the treatment of hypertension. Delapril An ACE inhibitor indicated in the treatment of essential hypertension. Vincamine Vincamine is a monoterpenoid indole alkaloid obtained from the leaves of Vinca minor with a vasodilatory property. Studies indicate that vincamine increases the regional cerebral blood flow. Linsidomine Not Annotated Cyclopenthiazide Cyclopenthiazide is a thiazide diuretic with antihypertensive properties. In a double blind, randomized crossover study, cyclopenthiazide was effective in reducing diastolic blood pressure in mildly hypertensive non-insulin dependent diabetic patients... Epanolol Epanolol is an beta blocker. Muzolimine Not Annotated Xipamide A diuretic indicated in the treatment of edema. Candesartan An angiotensin-receptor blocker indicated in the treatment of hypertension. Metyrosine A tyrosine 3-monooxygenase inhibitor used to treat excessive sympathetic stimulation in pheochromocytoma. Deserpidine An alkaloid that has been used to manage hypertension. Rescinnamine 为treatment of hypertension. Sitaxentan Investigated for use/treatment in pulmonary hypertension, connective tissue diseases, hypertension, and congestive heart failure. Ambrisentan A selective type A endothelin receptor antagonist used to treat primary pulmonary arterial hypertension and pulmonary arterial hypertension based on diagnostic classifications. Riociguat A stimulator of soluble guanylate cyclase indicated for the management of persistent or recurrent chronic thromboembolic pulmonary hypertension and pulmonary arterial hypertension. Macitentan An endothelin receptor antagonist used to manage pulmonary arterial hypertension to delay disease progression. Guanoxan Guanoxan is an antihypertensive agent similar in its mechanism of action to guanethidine; may cause liver damage. Guanoxan was approved in the UK but was withdrawn from the market due... Guanoxabenz Not Annotated Tolonidine Not Annotated Guanazodine Not Annotated Methoserpidine Not Annotated Guanoclor Not Annotated Esmolol A cardioselective beta-adrenergic blocker used for the short-term control of ventricular rate and heart rate in various types of tachycardia, including perioperative tachycardia and hypertension. Practolol Used in the emergency treatment of cardiac arrhythmias. Esatenolol Esatenolol is a beta blocker. Bevantolol 为treatment of angina pectoris and hypertension. Cicletanine Cicletanine is under investigation for the treatment of Diabetes, Hypokalemia, Hyponatremia, and Arterial Hypertension. Dexniguldipine Not Annotated Tocopherylquinone Not Annotated Benazeprilat Not Annotated Terazosin An alpha-1 adrenergic antagonist used in the treatment of symptomatic benign prostatic hyperplasia and management of hypertension. Fosinoprilat Fosinoprilat is the active phosphinic acid metabolite of prodrug fosinopril, which is activated by esterases in vivo. It binds zinc with phosphinic acid group. Ramiprilat The active metabolite of the prodrug Ramipril. Perindoprilat The active metabolite of the prodrug Perindopril. Quinaprilat The active metabolite of the prodrug quinapril. Timolol A non-selective beta adrenergic blocker used in the treatment of elevated intraocular pressure in ocular hypertension or open angle glaucoma. Carteolol β肾上腺素拮抗剂用于治疗arrhythmia, angina, hypertension, and glaucoma. Propranolol A non-selective beta adrenergic antagonist used to treat hypertension, angina, atrial fibrillation, myocardial infarction, migraine, essential tremor, hypertrophic subaortic stenosis, and pheochromocytoma. Alprenolol 为treatment of hypertension, angina, and arrhythmia Pindolol A beta adrenoceptor antagonist used to treat hypertension, edema, ventricular tachycardias, and atrial fibrillation. Nadolol A non-selective beta-adrenergic antagonist used for the management of arrhythmias, angina pectoris, and hypertension. Penbutolol A beta-adrenergic antagonist used for the management of mild to moderate arterial hypertension, alone or in combination with other antihypertensive agents. Oxprenolol A non-selective beta-adrenergic antagonist used to treat hypertension, angina pectoris, arrhythmias, and anxiety. Bupranolol Used to manage hypertension and tachycardia. Also used to treat glaucoma. Cloranolol Not Annotated Dexpropranolol Not Available Rauwolfia serpentina root Rauwolfia alkaloids are indicated in the treatment of hypertension . Rauwolfia alkaloids have been used for relief of symptoms in agitated psychotic states such as schizophrenia; however, use as antipsychotics... Nitroglycerin A nitrate vasodilator used to treat or prevent angina, heart failure, hypertension, and anal fissures. Tadalafil A phosphodiesterase 5 inhibitor used to treat erectile dysfunction, benign prostatic hyperplasia, and pulmonary arterial hypertension. Landiolol An ultra short-acting selective beta-blocker used for rapid ventricular rate control in cases of supraventricular tachycardia. Eplerenone An aldosterone receptor antagonist used to improve survival of patients with symptomatic heart failure and to reduce blood pressure. Angiotensin 1-7 TXA127 has been investigated for the treatment of Miscellaneous Peripheral Blood Cell Abnormalities. Furosemide A loop diuretic used to treat hypertension and edema in congestive heart failure, liver cirrhosis, renal disease, and hypertension. Azilsartan medoxomil An angiotensin II receptor blocker used to treat hypertension alone or in combination with other antihypertensive agents, such as chlorthalidone. Clevidipine A dihydropyridine L-type calcium channel blocker used to lower blood pressure when oral antihypertensive therapy is not feasible or not desirable. Levamlodipine A calcium channel blocker used to treat hypertension. Nifedipine A dihydropyridine calcium channel blocker indicated for the management of several subtypes of angina pectoris, and hypertension. Spironolactone An aldosterone receptor antagonist used for the treatment of hypertension, hyperaldosteronism, edema due to various conditions, hirsutism (off-label) and hypokalemia. Verapamil A non-dihydropyridine calcium channel blocker used in the treatment of angina, arrhythmia, and hypertension. Buthiazide A diuretic indicated in the treatment of edema caused by congestive heart failure, as well as hepatic and renal diseases. Dasiglucagon A glucagon analog used to treat severe hypoglycemia in pediatric and adult patients with diabetes. Epicaptopril Not Available QGC-001 QGC001 has been used in trials studying the treatment of Essential Hypertension. AR-9281 Investigated for use/treatment in hypertension. y - 27632 y - 27632 is an inhibitor of Rho-associated protein kinase. It inhibits calcium sensitization to affect smooth muscle relaxation. Cilazaprilat Not Annotated - Drugs & Drug Targets